COMPARATIVE ANTIOXIDANT ACTIVITY OF SOME OCULAR TISSUE LUBRICANTS FROM ROMANIAN MARKET

References: 17th International Multidisciplinary Scientific GeoConference SGEM 2017, www.sgem.org, SGEM2017 Conference Proceedings, ISBN 978-619-7408-12-6 / ISSN 1314-2704, 29 June - 5 July, 2017, Vol. 17, Issue 61, 593-600 pp, DOI: 10.5593/sgem2017/61/S25.078

ABSTRACT

Dry eye disease became an important problem of public health, because of its increasing incidence, caused by pollution, global warming and expanding work on video terminals. Under the actual circumstances in which the ocular tissue lubricant, commonly referred as artificial tears, market includes every day new comers, the authors were interested to find out how the various active pharmacological agents impact on the eye surface. This different impact on the eye might be able to help practitioners to better individualize artificial tears indication, for more satisfactory results on patients. The present paper emphasize the total antioxidant activity of different ocular tissue lubricants frequently commercialized on Romanian market, including four different active principles, sodium hyaluronate, hydroxypropyl-guar, hypromelose and carboxymethylcellulose, in order to find any existing correlation between the chemical characteristics and the effectiveness of an artificial tear. Comparative determination of the total antioxidant capacity of the artificial tears was quantified through photochemiluminescence method, by comparison with a standard substance specific for calibration, Trolox, as tocopherol derivative (in ACL method) using a Photochem, Analytik Jena AG apparatus. The obtained results might improve the efficiency of ocular tissue lubricant drops by revealing the different reactivity of these products under the sun influence, thus providing new criteria for the therapy selection.

Keywords: ocular lubricant, artificial tears, total antioxidant activity