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DOI: 10.5593/SGEM2016/HB63/S08.022

AN ADVANCED MODEL OF THE VIRAL ENTRY THE CELL OF LIVING ORGANISM AND ITS PROSPECTS FOR THE FUTURE BIOTECHNOLOGY IN HEALTHCARE AND PHARMACEUTICS

O. Alexandrova
Friday 11 November 2016

References: 16th International Multidisciplinary Scientific GeoConference SGEM 2016, SGEM Vienna GREEN Extended Scientific Sessions, www.sgemviennagreen.org, SGEM2016 Conference Proceedings, ISBN 978-619-7105-79-7 / ISSN 1314-2704, 2 - 5 November, 2016, Book 6 Vol. 3, 169-176pp, DOI: 10.5593/SGEM2016/HB63/S08.022

ABSTRACT
Background: A mechanism of a cell transports large molecules, i.e. macropinocytosis, is one of the open problems in the current biology. However, understanding of present problem allows for highlighting ample biological and medical questions. A major focus of this manuscript is to advance a model of macropinocytosis applied to the viral entry the cell of living organism.
Methods: The investigation was carried out using results of quantum biology that allowed us to calculate an electromagnetic wave influence of nano objects, such as humic particles or viruses, on the cell membrane. To explore this wave effect, the theory of the Rayleigh – Taylor instability was applied and extended in the case of the adiabatic process defined with the entropy gradient arisen on the membrane and followed by adsorbed virus.
Results: The main findings of the study is an advanced model that hypothesizes the viral entry the cell as a sequence of the following stages: the formation of entropy perturbation within the binding site dS where virus was adsorbed on the cell membrane; smearing of entropy perturbation reaching its critical parameter; appearance and development of hydrodynamic perturbation of the cell membrane observed at experiment as ripples and pits; mush of virus bound to dS into the corresponding pit accompanying by its encapsulation and the formation of vesicle.
Conclusions: An advance model highlights the mechanism of the viral entry the cell that takes us a good chance to find the alternative methods to treat a lot of dangerous illnesses, especially caused by the viral infection. This model also evidences a competitive effect of humic particles by the entry the cell of living organism.

Keywords: viral infection, model of macropinocytosis, virus entry the cell, Rayleigh–Taylor instability; Electron Paramagnetic Resonance Imaging

PAPER DOI: 10.5593/SGEM2016/HB63/S08.022, AN ADVANCED MODEL OF THE VIRAL ENTRY THE CELL OF LIVING ORGANISM AND ITS PROSPECTS FOR THE FUTURE BIOTECHNOLOGY IN HEALTHCARE AND PHARMACEUTICS

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