DBPapers
DOI: 10.5593/SGEM2016/B61/S25.075

HISTOPATHOLOGIC AND MORPHOMETRIC ASPECTS OF THE DUODENAL GLANDS IN THE UPPER DIGESTIVE TRACT PATHOLOGY

M.Fortofoiu, M.C.Fortofoiu
Wednesday 7 September 2016 by Libadmin2016

References: 16th International Multidisciplinary Scientific GeoConference SGEM 2016, www.sgem.org, SGEM2016 Conference Proceedings, ISBN 978-619-7105-68-1 / ISSN 1314-2704, June 28 - July 6, 2016, Book6 Vol. 1, 567-574 pp

ABSTRACT

Introduction: Our aim was to establish whether correlations exist between the type of upper digestive tract pathology, presence or absence of duodenal glands (DGs) hyperplasia, the histological type of hyperplasia and what type of morphometric parameters might be modified in the DGs in order to produce hyperplasia.
Patients and Methods: We have conducted this study on 414 patients both male and female who required upper gastrointestinal endoscopy. Histology staining included Hematoxylin-Eosin, Goldner-Szekelly, Periodic Acid Schiff hematoxylin Mayer-Alcian blue, Alcian blue; Periodic Acid-Schiff hematoxylin Mayer and Giemsa modified. We performed the morphometric study with software to assess quantitatively the glandular hyperplasia. The results were statistically processed by using descriptive statistic for testing distribution and for comparing means (p value ≤ 0.05 was significant).
Results: Upper endoscopy revealed changes such as gastritis 171 cases, ulcers 137 cases and gastric tumors 78 cases; 28 patients had no endoscopic changes, being included in the control group. The comparison between the mean values of morphometric parameters obtained in the control group and mean values of morphometric parameters obtained in patients with gastritis, peptic ulcers and gastric tumors by using one sample T test revealed the presence or absence of differences between these values and how significant was this difference.
Conclusions: Upper gastrointestinal pathology exert influences on the first portion of the duodenum causing changes in duodenal mucosa and submucosa. The most frequent and characteristic histopathological changes at the duodenal mucosa and submucosa is duodenal glands hyperplasia from the first portion of the duodenum.

Keywords: duodenal glands, hyperplasia, gastrointestinal cancers, immunohistochemical assessment