DBPapers
DOI: 10.5593/SGEM2014/B61/S25.045

CORRELATION BETWEEN ANTIOXIDANT ACTIVITY OF VEGETAL SUPPLEMENT AND AGE RELATED MACULOPATHY

J. Sanda,T. Negreanu-Pîrjol, F. Roncea, B.S. Negreanu-Pîrjol, R. Sirbu, A.C.Lepadatu, H. Miresan
Wednesday 1 October 2014 by Libadmin2014

References: 14th International Multidisciplinary Scientific GeoConference SGEM 2014, www.sgem.org, SGEM2014 Conference Proceedings, ISBN 978-619-7105-20-9 / ISSN 1314-2704, June 19-25, 2014, Book 6, Vol. 1, 321-328 pp

ABSTRACT
Because ARM (age related maculopathy) is one of the leading causes of
irreversible visual loss among people aged 45 - 65 years in the world and as well in Romania, the aim of this paper is to reveal any differences of therapy response which might be related to different antioxidant activity of vegetal supplement (tablets). This supplement contains only Sunphenon EGCG 90% dry extract from Camellia sinensis leaves, standardized in 90% epigallocatechine gallate. Epigallocatechine gallate acts as a powerful antioxidant compound that neutralizes reactive oxygen species resulted during metabolic processes at eye level, contribute to the normalization functionality of nerve cells and, in particular, of the retina; protects and nourishes the ocular structures (optic nerve, retina) affected by degenerative processes. For this reason we used 4 groups of 20 persons of each one divided after gender (males and females) and age (45 – 65 years) and different diseases (one third with diabetic maculopathy). From these 4 groups one was the control that received no treatment. Clinical evaluation of this supplement action was done by Amsler ophthalmologic test, visual acuity, visual field, ophthalmoscopic aspect of the fundus of the eye, before and after the treatment. The antioxidant activity of this supplement was determined by a hotochemiluminescence method (PCL), based on the multiple acceleration of a natural reaction leading to the generation of a superoxide anion radical. The measured antioxidative capacity is then quantified by comparison with a standard substance used for calibration, Trolox as tocopherol derivative (in ACL method) using a Photochem, Analytik Jena AG apparatus. The antioxidant capacity results show that after the treatment based on epigallocatechine gallate supplement, some of visual parameters improved or at least remained the same compared to control group without treatment, in which the ophthalmologic situation got worse, more or less. Preliminary results emphasized the importance of this supplement in age related maculopathy.

Keywords: age related maculopathy, antioxidant activity, vegetal supplement,
epigallocatechine gallate