BIOLOGICAL ACTIVITY OF SOME NEW LN(III) COMPLEX COMPOUNDS BASED ON BIGUANIDE DERIVATIVES

References: 14th International Multidisciplinary Scientific GeoConference SGEM 2014, www.sgem.org, SGEM2014 Conference Proceedings, ISBN 978-619-7105-20-9 / ISSN 1314-2704, June 19-25, 2014, Book 6, Vol. 1, 285-292 pp

ABSTRACT
The N-substituted biguanide derivatives have shown a considerable attention for their antidiabetic and antimalarial activity and for the therapeutic treatment of pain, anxiety and memory disorders as 5-HT3 serotonin receptors. The biological action of these complexes on the human body may be explained by the formation of these compounds. We have synthesized a new series of La(III) and Ce(III) complexes based on Nsubstituted biguanide. These derivatives were characterized by elemental analysis, molar electrical conductivity, IR, UV-VIS and electronic spectroscopy. In the present paper we report the biological effects of the new La(III) and Ce(III) compounds on the saprophyte bacterian Halomonas sp. isolated from Romanian Black Sea Coast. Also, the new complexes and ligand were tested against different Gram positive (Staphylococcus coagulase positive, Streptococcus β-haemolitic A group, Streptococcus β-haemolitic B group, Streptococcus faecalis, Bacillus cereus, Corynaebacterium dyphtheriae), Gram negative (Pseudomonas aeruginosa, Shigella flexneri, Escherichia coli, Salmonella B group) bacteria strains and fungal (Candida albicans, Saccharomices cerevisiae) species for their antimicrobial action. The results emphasize that all complex compounds present antimicrobial activity compared with the ligand, against most of the tested species.

Keywords: Ln(III) complex compounds, N- substituted biguanide, biological activity