DBPapers
DOI: 10.5593/SGEM2014/B61/S24.016

MESOSTRUCTURED ALUMINOSILICATES AS CARRIERS FOR DOXYCYCLINE-BASED DRUG DELIVERY SYSTEMS

R. Mitran, S. Nastase, L. Bajenaru, C. Matei, D. Berger
Wednesday 1 October 2014 by Libadmin2014

References: 14th International Multidisciplinary Scientific GeoConference SGEM 2014, www.sgem.org, SGEM2014 Conference Proceedings, ISBN 978-619-7105-20-9 / ISSN 1314-2704, June 19-25, 2014, Book 6, Vol. 1, 113-120 pp

ABSTRACT
A mesostructured AlSBA-15 material has been obtained by direct “acid-free”
sol-gel method using aluminum sulfate and tetraethyl orthosilicate as precursors and triblock copolymer Pluronic P123 as structure-directing agent. 3-aminopropyl moieties have been introduced by a post-synthesis grafting procedure and the resulting mesoporous materials have been applied as carriers for doxycycline delivery systems. The mesostructured supports and doxycycline-loaded materials have been characterized by small and wide angle powder X-ray diffraction, N2 adsorption-desorption isotherms, FT-IR spectroscopy, scanning electron microscopy coupled with energy dispersive Xray analysis, as well as thermal analysis. The drug release behavior is discussed in light of the doxycycline-aluminosilicate interactions.

Keywords: mesoporous aluminosilicate, AlSBA-15, acid-free medium, doxycycline,
drug release