DBPapers
DOI: 10.5593/SGEM2014/B61/S24.008

DOXYCYCLINE ENCAPSULATION STUDIES INTO MESOPOROUS SBA-15 SILICA TYPE CARRIERS AND IN VITRO RELEASE

R. Mitran, S. Nastase,C. Stan, A. Iorgu, C. Matei, D. Berger
Wednesday 1 October 2014 by Libadmin2014

References: 14th International Multidisciplinary Scientific GeoConference SGEM 2014, www.sgem.org, SGEM2014 Conference Proceedings, ISBN 978-619-7105-20-9 / ISSN 1314-2704, June 19-25, 2014, Book 6, Vol. 1, 53-60 pp

ABSTRACT
The doxycycline encapsulation procedure on mesoporous SBA-15 silica has
been studied and optimized. The supports (SBA-15 and aminopropyl-modified SBA-15) and hybrid materials containing doxycycline were synthesized and characterized by small and wide angle powder X-ray diffraction, N2 adsorption-desorption isotherms, FT-IR spectroscopy, scanning electron microscopy and thermal analysis. Doxycycline uptake and its release profiles in phosphate buffer solution at pH 5.5 and 37 oC were determined by UV-VIS spectroscopy. The doxycycline encapsulation protocol onto the mesoporous supports was established.

Keywords: mesoporous silica, doxycycline, drug delivery systems, SBA-15